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The two most popular explanations of origin are that the belief goes back to pagan times when we believed in tree spirits, or that we are invoking Christ’s protection by referring to the wood of the Cross. The former is nothing but guesswork, based on the conviction that all superstitions must be ancient, and it has the usual problem of spanning thousands of years with no evidence at all of its existence, or, for that matter, any evidence that ‘we’ ever believed in tree spirits.
Vosoritide的成功，再次向外界证明了罕见病赛道的巨大潜力：ACH看似是罕见病，但明确的致病机制、典型的临床表现，叠加数万级的患者基数和迫切、长期的治疗需求，使其成为了一个极具开发价值的 “不罕见” 罕见病市场。